醋酸泼尼松联合硫唑嘌呤对自身免疫性肝炎患者血清趋化因子水平的影响观察

Effect of Prednisone Acetate Combined with Azathioprine on Serum Chemokine Levels in Patients with Autoimmune Hepatitis

目的探讨醋酸泼尼松联合硫唑嘌呤对自身免疫性肝炎(AIH)患者血清趋化因子水平的影响观察。方法选取86例AIH患者,以随机奇偶编号将患者进行分组:观察组和对照组各43例。对照组予以单纯醋酸泼尼松治疗,观察组在对照组基础联合硫唑嘌呤治疗,均持续治疗6个月。分别于治疗前后,观察两组患者血清中的趋化因子受体-6(CCR6)、巨噬细胞炎性蛋白20抗体(CCL20)、趋化因子10/干扰素诱导蛋白10(CXCL10)以及血清谷氨酰转肽酶(GGT)、免疫球蛋白G4(LgG4)指标。记录两组治疗期间的不良反应发生情况。结果观察组血清CCR6、CCL20、CXCL10水平均明显低于对照组血清CCR6、CCL20、CXCL10水平,差异学统计有意义(P<0.05)。观察组血清GGT、LgG4水平明显低于对照组血清GGT、LgG4水平,差异有统计学意义(P<0.05)。观察组的不良反应发生率为48.84%,明显低于对照组的72.09%(χ2=4.864,P=0.027)。结论醋酸泼尼松联合硫唑嘌呤治疗自身免疫性肝炎可以降低患者的血清趋化因子的水平,能改善肝功能,提高患者的临床疗效且降低不良反应的发生。

Objective To investigate the effect of prednisone acetate combined with azathioprine on serum chemokine levels in patients with autoimmune hepatitis(AIH).Methods 86 AIH patients diagnosed were selected and divided into observation group:control group(cases)=43:43 by random parity number.The control group was treated with prednisone acetate alone,The observation group was treated with azathioprine combined with the control group for 6 months.Before and after treatment,the serum levels of CCR6,CCL20,CXCL10,GGT and lgg4 in the two groups were observed.The incidence of adverse reactions in the two groups was recorded.Results the serum levels of CCR6,CCL20 and CXCL10 in the observation group were significantly lower than those in the control group(P<0.05).The serum GGT and lgg4 levels in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 48.84%,It was significantly lower than 72.09%of the control group(χ2=4.864,P=0.027).Conclusion prednisone acetate combined with azathioprine in the treatment of autoimmune hepatitis can reduce the level of serum chemokines,improve liver function,improve the clinical efficacy and reduce the incidence of adverse reactions.