中青年非酒精性脂肪肝患者地中海膳食干预效果评价

Evaluation of Mediterranean Dietary Intervention in Middle-aged and Young Patients with Nonalcoholic Fatty Liver Disease

目的评价地中海膳食干预对中青年非酒精性脂肪肝(NAFLD)患者血清生化指标的影响。方法将108例NAFLD患者随机分为干预组和对照组,每组各54例。干预组实行地中海膳食干预,对照组保持原有膳食方式,观察地中海膳食对肝功能、血脂指标的影响。结果干预后,干预组NAFLD患者的谷氨酰转肽酶、碱性磷酸酶、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白等与对照组比较均显著改善(P<0.05)。结论调整膳食结构能有效改善NAFLD患者的肝细胞损伤和脂质代谢情况。

Objective To evaluate the effect of Mediterranean diet on serum biochemical indexes in middle-aged and young patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 108 patients with NAFLD were randomly divided into an intervention group and a control group,with 54 patients in each group.The intervention group received Mediterranean diet intervention,while the control group maintained its original dietary pattern.The effects of Mediterranean diet on liver function and blood lipids were observed.Results After intervention,the indicators glutamyltranspeptidase,alkaline phosphatase,triglycerides,total cholesterol,high-density lipoprotein,and low-density lipoprotein in the intervention group were significantly improved compared with those in the control group(P<0.05).Conclusion Adjusting dietary structure can effectively improve hepatocyte damage and lipid metabolism in patients with NAFLD.