普罗帕酮与胺碘酮治疗心律失常的临床效果及其对血清超敏C反应蛋白的影响分析

Analysis of the clinical effect of propafenone and amiodarone in the treatment of arrhythmia and its influence on serum high-sensitivity C-reactive protein

目的分析普罗帕酮与胺碘酮治疗心律失常的临床效果及其对血清超敏C反应蛋白的影响。方法100例心律失常患者,采用随机数字表法分为对照组和观察组,每组50例。对照组患者给予普罗帕酮治疗,观察组患者给予胺碘酮治疗。比较两组病情改善时间、住院时间,治疗前后心功能等级、血清超敏C反应蛋白水平,治疗效果,不良反应发生情况。结果观察组患者的病情改善时间为(6.10±1.67)d、住院时间为(8.56±2.67)d,均短于对照组的(9.78±2.78)、(12.12±3.89)d,差异具有统计学意义(P<0.05)。治疗前,两组患者的心功能等级、血清超敏C反应蛋白水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的心功能等级、血清超敏C反应蛋白水平均较治疗前改善,且观察组心功能等级(1.56±0.13)级、血清超敏C反应蛋白(7.21±1.55)mg/L均显著低于对照组的(2.71±0.45)级、(12.28±2.58)mg/L,差异具有统计学意义(P<0.05)。观察组治疗总有效率为100.00%,高于对照组的80.00%,差异具有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论胺碘酮治疗心律失常的临床效果更好,其对改善血清超敏C反应蛋白作用更显著。

Objective To analyze the clinical effect of propafenone and amiodarone in the treatment of arrhythmia and its influence on serum high-sensitivity C-reactive protein.Methods A total of 100 patients with arrhythmia were divided into control group and observation group according to the random numerical table,with 50 cases in each group.The control group was treated with propafenone,and the observation group was treated with amiodarone.The recovery time,hospitalization time,cardiac function grading,serum high-sensitivity C-reactive protein level,therapeutic effect,and occurrence of adverse reactions were compared between the two groups.Results The recovery time and hospitalization time in the observation group were(6.10±1.67)d and(8.56±2.67)d,both of which were shorter than those of(9.78±2.78)and(12.12±3.89)d in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in cardiac function grading and serum high-sensitivity C-reactive protein level between the two groups(P>0.05).After treatment,the cardiac function grading and serum high-sensitivity C-reactive protein level in the two groups were improved compared with those before treatment in this group;the cardiac function grading of(1.56±0.13)grades and serum high-sensitivity C-reactive protein of(7.21±1.55)mg/L in the observation group were significantly lower than those of(2.71±0.45)and(12.28±2.58)mg/L in the control group;the differences were statistically significant(P<0.05).The total effective rate in the observation group was 100.00%,which was higher than that of 80.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of amiodarone in the treatment of arrhythmia is better,and its effect on the improvement of serum high-sensitivity C-reactive protein is more significant.