瑞舒伐他汀治疗动脉粥样硬化的临床效果分析

Analysis of clinical effects of rosuvastatin in the treatment of atherosclerosis

目的分析瑞舒伐他汀治疗动脉粥样硬化的临床效果。方法50例动脉粥样硬化患者,随机分为对照组和观察组,每组25例。对照组患者给予常规药物治疗,观察组患者在对照组基础上给予瑞舒伐他汀治疗。比较两组患者临床疗效、不良反应发生情况及治疗前后血脂指标、颈动脉内膜中层厚度。结果治疗后,两组患者低密度脂蛋白胆固醇、总胆固醇、甘油三酯、颈动脉内膜中层厚度均低于本组治疗前,高密度脂蛋白胆固醇高于本组治疗前,且观察组患者低密度脂蛋白胆固醇(2.31±0.24)mmol/L、总胆固醇(3.61±0.11)mmol/L、甘油三酯(1.42±0.11)mmol/L、颈动脉内膜中层厚度(0.85±0.12)mm均低于对照组的(2.81±0.45)mmol/L、(4.62±0.15)mmol/L、(1.82±0.34)mmol/L、(0.94±0.11)mm,高密度脂蛋白胆固醇(1.85±0.38)mmol/L高于对照组的(1.46±0.33)mmol/L,差异具有统计学意义(P<0.05)。观察组患者治疗总有效率为96.00%,高于对照组的72.00%,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论常规药物与瑞舒伐他汀联合治疗动脉粥样硬化的效果确切,可更好调节总胆固醇、低密度脂蛋白胆固醇、甘油三酯、高密度脂蛋白胆固醇,改善颈动脉情况,安全性高,值得推广。

Objective To analyze the clinical effects of rosuvastatin in the treatment of atherosclerosis.Methods A total of 50 patients with atherosclerosis were randomly divided into control group and observation group,with 25 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with rosuvastatin on the basis of control group.The clinical efficacy,occurrence of adverse reactions,blood lipid indexes and carotid intima media thickness before and after treatment were compared between the two groups.Results After treatment,the low density lipoprotein cholesterol,total cholesterol,triglyceride,and carotid intima media thickness in the two groups were lower than those before treatment in this group,while high density lipoprotein cholesterol was higher than that before treatment in this group;the observation group had low density lipoprotein cholesterol of(2.31±0.24)mmol/L,total cholesterol of(3.61±0.11)mmol/L,triglyceride of(1.42±0.11)mmol/L,and carotid intima media thickness of(0.85±0.12)mm,which were lower than those of(2.81±0.45)mmol/L,(4.62±0.15)mmol/L,(1.82±0.34)mmol/L,and(0.94±0.11)mm in the control group;the high density lipoprotein cholesterol of(1.85±0.38)mmol/L in the observation group was higher than that of(1.46±0.33)mmol/L in the control group;the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.00%,which was higher than that of 72.00%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of conventional drugs and rosuvastatin has a definite effect in the treatment of atherosclerosis,which can better regulate total cholesterol,low density lipoprotein cholesterol,triglyceride and high density lipoprotein cholesterol,and improve the condition of carotid artery.It is safe and worthy of promotion.