慢性阻塞性肺疾病急性加重期患者采取阿奇霉素联合头孢类药物治疗的效果分析

Analysis of effect of azithromycin combined with cephalosporins in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病(慢阻肺)急性加重期患者采用阿奇霉素联合头孢类药物进行治疗的效果。方法82例慢阻肺急性加重期患者,根据治疗方法不同分为常规组和实验组,每组41例。常规组患者给予头孢类药物治疗,实验组患者给予阿奇霉素联合头孢类药物治疗。对比两组临床疗效及治疗前后肺功能指标[呼气峰值流速(PEF)、第1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)]、生活质量评分。结果实验组治疗总有效率为97.6%,显著高于常规组的80.5%,差异具有统计学意义(P<0.05)。治疗后,实验组PEF(6.64±0.72)L/s、FEV1/FVC(83.92±2.78)%均显著高于常规组的(5.15±0.78)L/s、(77.59±3.26)%,差异具有统计学意义(P<0.05)。治疗后,两组物质生活状态、社会功能、躯体功能及心理功能评分均高于本组治疗前,且实验组物质生活状态评分(84.33±6.96)分、社会功能评分(82.29±6.02)分、躯体功能评分(82.14±4.53)分、心理功能评分(81.93±4.55)分高于常规组的(75.20±5.99)、(73.54±4.23)、(73.25±4.06)、(74.08±4.44)分,差异具有统计学意义(P<0.05)。结论慢阻肺急性加重期患者采用阿奇霉素联合头孢类药物进行治疗,不仅能够有效减轻患者临床病症,还能提高其肺功能与生活质量,值得临床推广。

Objective To discuss the effect of azithromycin combined with cephalosporins in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 82 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into conventional group and experimental group according to different treatment methods,with 41 cases in each group.The conventional group was treated with cephalosporins,while the experimental group was treated with azithromycin and cephalosporins.Both groups were compared in terms of clinical efficacy,pulmonary function indexes[peak expiratory flow rate(PEF),forced expiratory volume in one second/forced vital capacity(FEV1/FVC)]and quality of life score before and after treatment.Results The total effective rate in the experimental group was 97.6%,which was significantly higher than that of 80.5%in the conventional group,and the difference was statistically significant(P<0.05).After treatment,PEF of(6.64±0.72)L/s and FEV1/FVC of(83.92±2.78)%in the experimental group were significantly higher than those of(5.15±0.78)L/s and(77.59±3.26)%in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the scores of material life status,social function,physical function and psychological function in the two groups were higher than those before treatment in this group;the experimental group had material life status score of(84.33±6.96)points,social function score of(82.29±6.02)points,physical function score of(82.14±4.53)points and psychological function score of(81.93±4.55)points,which were higher than those of(75.20±5.99),(73.54±4.23),(73.25±4.06),and(74.08±4.44)points in the conventional group;the differences were statistically significant(P<0.05).Conclusion In the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease,the combination of azithromycin and cephalosporins can not only effectively reduce the clinical symptoms of patients,but also improve their pulmonary function and quality of life,which is worthy of clinical promotion.