利司那肽联合甘精胰岛素治疗口服药控制不佳的2型糖尿病患者的效果观察

Observation on the effect of lixisenatide combined with insulin glargine in the treatment of type 2 diabetes mellitus patients poorly controlled on oral antidiabetic drugs

目的观察利司那肽联合甘精胰岛素治疗口服药控制不佳的2型糖尿病患者的效果。方法120例口服药控制不佳的2型糖尿病患者,随机分为观察组和对照组,每组60例。对照组应用甘精胰岛素治疗,观察组在对照组基础上联合应用利司那肽注射液治疗。比较两组患者的血糖指标[空腹血糖(FBG)及三餐餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛功能指标[空腹C肽(FCP)、餐后2 h C肽(2 h PCP)、体质量指数(BMI)]水平及不良反应发生情况。结果治疗后,观察组患者的2 h PG(9.71±1.44)mmol/L、HbA1c(6.81±0.86)%均显著低于对照组的(10.65±1.98)mmol/L、(7.26±0.74)%,差异有统计学意义(P<0.05);两组患者的FBG水平比较差异无统计学意义(P>0.05)。治疗后,观察组患者的BMI(24.09±1.14)kg/m2显著低于对照组的(24.83±1.01)kg/m2,差异有统计学意义(P<0.05);两组患者的FCP、2 h PCP水平比较差异均无统计学意义(P>0.05)。观察组患者的不良反应发生率3.3%显著低于对照组的13.3%,差异有统计学意义(P<0.05)。结论采用利司那肽联合甘精胰岛素对口服药控制不佳的2型糖尿病患者的血糖进行控制,可以显著降低餐后血糖水平,其治疗效果明显,而且药物的不良反应较少,安全可靠,可以广泛在2型糖尿病患者中使用。

Objective To observe the effect of lixisenatide combined with insulin glargine in the treatment of type 2 diabetes mellitus patients poorly controlled on oral antidiabetic drugs.Methods A total of 120 cases of type 2 diabetes mellitus patients poorly controlled on oral antidiabetic drugs were randomly divided into observation group and control group,with 60 cases in each group.The control group was treated with insulin glargine,and the observation group was treated with lixisenatide injection on the basis of control group.Both groups were compared in terms of blood glucose indexes[fasting blood glucose(FBG),2 h postprandial glucose(2 h PG),glycosylated hemoglobin(HbA1c)],islet function indexes[fasting C-peptide(FCP),2 h postprandial C-peptide(2 h PCP),body mass index(BMI)],and the occurrence of adverse reactions.Results After treatment,the 2 h PG of(9.71±1.44)mmol/L and HbA1c of(6.81±0.86)%in the observation group were significantly lower than those of(10.65±1.98)mmol/L and(7.26±0.74)%in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in FBG levels between the two groups(P>0.05).After treatment,the BMI of(24.09±1.14)kg/m2 in the observation group was significantly lower than that of(24.83±1.01)kg/m2 in the control group,and the difference was statistically significant(P<0.05).The differences in FCP and 2 h PCP levels between the two groups were not statistically significant(P>0.05).The incidence of adverse reactions in the observation group was 3.3%,which was significantly lower than that of 13.3%in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of lixisenatide and insulin glargine can significantly reduce the postprandial blood glucose level in type 2 diabetes mellitus patients poorly controlled on oral antidiabetic drugs,and its therapeutic effect is obvious,and the adverse reactions are less.It is safe and reliable,and can be widely used in type 2 diabetes mellitus patients.