盐酸氨溴索治疗老年慢性阻塞性肺疾病合并肺感染的临床效果

Clinical Effect of Ambroxol Hydrochloride in Treatment of Senile Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Infection

目的:分析盐酸氨溴索对老年慢性阻塞性肺疾病合并肺感染的临床效果。方法:选取2020年10月—2022年6月淮安市淮安医院收治的老年慢性阻塞性肺疾病合并肺感染患者62例为观察对象,根据随机数字表法分为对照组和观察组,各31例。对照组给予常规治疗,观察组在对照组基础上联合盐酸氨溴索治疗,比较两组患者临床疗效、症状体征消失时间、肺功能指标[肺活量(FVC)、第1 s用力呼气容积(FEV1)、FEV1占FVC比值(FEV_(1)/FVC)]、肺部感染情况[肺部感染评分(CPIS)]、不良反应发生率。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.023);观察组胸闷、呼吸困难、咳嗽、咯痰消失时间短于对照组,差异有统计学意义(P=0.000);治疗后,两组患者FVC、FEV1、FEV_(1)/FVC指标均升高,观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者CPIS评分均降低,观察组低于对照组,差异有统计学意义(P=0.000)。结论:盐酸氨溴索对老年慢性阻塞性肺疾病合并肺感染效果显著,可缩短症状缓解时间,促进肺功能恢复,不会增加不良反应。

Objective:To analyze the clinical effect of ambroxol hydrochloride on senile chronic obstructive pulmonary disease complicated with pulmonary infection.Methods:A total of 62 elderly patients with chronic obstructive pulmonary disease complicated with pulmonary infection admitted to Huai'an Huai'an Hospital from October 2020 to June 2022 were selected as the observation objects.According to the random number table method,they were divided into control group and observation group,with 31 cases in each group.The control group was given conventional treatment,and the observation group was treated with ambroxol hydrochloride on the basis of the control group.The clinical efficacy,disappearance time of symptoms and signs,lung function indicators[forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),ratio of FEV1 to FVC(FEV1/FVC)],lung infection status[pulmonary infection score(CPIS)],and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.023).The disappearance time of chest tightness,dyspnea,cough and expectoration in the observation group was shorter than that in the control group,and the difference was statistically significant(P=0.000).After treatment,the indexes of FVC,FEV1 and FEV1/FVC in both groups were increased,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the CPIS score in both groups was reduced,and the observation group was lower than the control group,and the difference was statistically significant(P=0.000).Conclusion:Ambroxol hydrochloride has a significant effect in senile chronic obstructive pulmonary disease complicated with pulmonary infection,which can shorten the time of symptom relief and promote the recovery of lung function,without increasing adverse reactions.