微小RNA在缺血性脑卒中的研究进展

Research advances of microRNA in ischemic stroke

微小RNA(microRNA,miRNA)是一种特殊RNA,其不直接翻译成蛋白质,在基因转录后水平发挥作用,是最先被研究的非编码RNA之一。miRNA在哺乳动物神经系统中表达丰富,参与调控神经退行性损伤、脑卒中、脑外伤等疾病。近年来的研究发现miRNA与缺血性脑卒中关系尤为密切。文章归纳总结了miRNA在缺血性脑卒中作为诊断和判断预后的生物标志物以及作为治疗靶点的脑保护机制最新进展,为以miRNA为核心的核酸治疗应用于临床提供借鉴与依据。

microRNA(miRNA),a class of specialized RNA,which does not translate into proteins directly,but plays a role in the post⁃transcriptional level of genes,and it is one of the first non⁃coding RNAs to be studied.miRNA is richly expressed in the mammalian nervous system,and is involved in the regulation of neurodegenerative injury,stroke,brain trauma and other diseases.Recent studies have found that miRNA is especially associated with ischemic stroke.This paper summarized the latest progress of miRNA as biomarkers for diagnosis and prognosis of ischemic stroke and brain protection mechanisms as therapeutic targets,providing reference and basis for the clinical application of nucleic acid therapy with miRNA as the core.