摘要
脑小血管病是严重危害我国人民健康的常见疾病,其中脑白质高信号(white matter hyperintensities,WMHs)在老年患者中最为常见。静脉溶栓是目前治疗急性缺血性卒中最有效的药物治疗方法。出血性转化(hemorrhagic transformation,HT)是急性缺血性卒中患者静脉溶栓后最常见的严重并发症。WMHs患者的血脑屏障破坏可增高静脉溶栓后HT风险,基质金属蛋白酶及S100B共同参与了WMHs及静脉溶栓后HT血脑屏障的破坏过程。WHM及HT的发病机制目前尚不完全清楚,而且轻中度WMHs是否会加重HT仍存在着争议。尽管如此,WMHs仍是HT的独立危险因素。
Cerebrovascular disease is a common disease that seriously endangers the health of Chinese people.White matter hyperintensities(WMHs)are the most common in elderly patients.Intravenous thrombolysis is currently the most effective drug treatment for acute ischemic stroke.Hemorrhagic transformation(HT)is the most common serious complication after intravenous thrombolysis in patients with acute ischemic stroke.The destruction of blood-brain barrier in patients of WMHs can increase the risk of HT after intravenous thrombolysis.Matrix metalloproteinases and S100B jointly participate in the destruction process of blood-brain barrier in WMHs and HT after intravenous thrombolysis.At present,the pathogenesis of WHM and HT is not completely clear,and whether mild and moderate WMHs will aggravate HT is still controversial.Nevertheless,WMHs are still the independent risk factor for HT.
作者
贾莹
郭鑫鑫
高焱
王英茹
牛佳义
李倩倩
施倩
杨珊珊
Jia Ying;Guo Xinxin;Gao Yan;Wang Yingru;Niu Jiayi;Li Qianqian;Shi Qian;Yang Shanshan(Department of Neurology,the First Affiliated Hospital of Harbin Medical University,Harbin 150000,China;Department of Neurosurgery,the First Hospital of Qiqihar,Qiqihar 161000,China)
出处
《国际脑血管病杂志》
2022年第12期939-943,共5页
International Journal of Cerebrovascular Diseases
基金
哈尔滨医科大学附属第一医院科研创新基金(2020M16)。
关键词
卒中
脑缺血
血栓溶解疗法
白质
脑出血
危险因素
Stroke
Brain ischemia
Thrombolytic therapy
White matter
Cerebral hemorrhage
Risk factors
