脓毒症相关miRNA的研究进展

Research progression of miRNA related to sepsis

脓毒症是指因严重感染引起宿主免疫反应失调的全身炎症反应综合征,其病情进展快、预后差,是重症医学科常见的危急重症。微小RNA(miRNA)通过与目的信使RNA(mRNA)结合,特异性抑制靶mRNA分子的翻译,从而影响基因表达。因此其可以作为脓毒症潜在的早期筛查生物标志物。本文就部分miRNA在脓毒症中的潜在作用机制进行综述。

Sepsis is a syndrome of systemic inflammatory response caused by severe infection,with rapid progression and poor prognosis.It is a common critical illness in intensive care medicine.MicroRNA(miRNA)affect gene expression by binding to target messenger RNA(mRNA)and specifically inhibiting the transla-tion of target mRNA molecules.Therefore,it can be used as a potential early screening biomarker for sepsis.This paper reviews the potential mechanisms of action of some miRNA-related genes in sepsis.