去甲斑蝥素在乳腺癌中的研究进展

Research progress of norcantharidin in breast cancer

乳腺癌是我国最常见的女性恶性肿瘤。传统中药及其提取物因具有单药多靶点、低毒的特点,成为乳腺癌治疗的研究热点。去甲斑蝥素是一种新型人工合成抗肿瘤药物,具有升白细胞、抗肿瘤的作用。其抗肿瘤作用机制包括抗血管生成,促进肿瘤细胞凋亡,抑制肿瘤细胞增殖、侵袭与转移等。以斑蝥为主要来源的中成药在乳腺癌的临床应用中贯穿全程。本文就近年来去甲斑蝥素在乳腺癌中的研究进展进行综述。

Breast cancer is the most common female malignant tumor in China.In the treatment of breast cancer,tradi-tional Chinese medicine(TCM)and its extracts have become a research hotspot because of their characteristics of single drug but multiple targets and low toxicity.Norcantharidin is a novel synthetic anti-cancer drug which can also raise the lev-el of leukocytosis.Its mechanism includes anti-angiogenesis,fueling cancer cell apoptosis,inhibiting cancer cell prolifera-tion,invasion and metastasis.Chinese patent medicines with cantharidin as the main source have been used throughout the whole clinical treatment of breast cancer.In this article,we mainly reviewed the research of norcantharidin in breast cancer in the last few years.