儿童炎症性肠病与口腔微生物的关系

Pediatric inflammatory bowel disease and oral microbiota

口腔与胃肠道相连,口腔健康可能与胃肠道的整体健康密切相关。炎症性肠病(inflammatory bowel disease,IBD)是一种病因不明,以慢性炎症为特征的肠道疾病,受宿主遗传、免疫调节、日常饮食和肠道微生物的影响。近年来,对IBD中微生物的研究表明,口腔微生物易位到肠道可能是克罗恩病和溃疡性结肠炎的微生物失调特征之一。小鼠实验表明,口腔细菌和酵母菌易位到下消化道可能会引发易感宿主的炎症,这为IBD的发展提供了机制研究的基础。口腔微生物可能在IBD的发生发展中起重要作用。该文就口腔微生物与儿童IBD之间的关系研究进展作一综述。

The oral cavity is continuous with the gastrointestinal tract and oral health may be closely linked with the overall health of the gastrointestinal tract.Inflammatory bowel disease(IBD)is an intestinal disorder characterized by chronic inflammation of unknown etiology,affected by host genetics,immunoregulation,daily diet,and the gut microbiota.Recent studies of the microbiome in IBD suggest that translocation of oral microbes to the gut may be a common feature of the microbial dysbiosis which is a signature of both pediatric Crohn′s disease and ulcerative colitis.Murine studies suggest that translocation of oral bacteria and yeasts to the lower gastrointestinal tract may trigger inflammation in susceptible hosts,providing a mechanistic link to the development of IBD.Oral microbiota may play an important role in the development of IBD.This article reviews the relationship between oral microbiota and pediatric IBD.