微流控芯片在循环肿瘤细胞分离捕获中的应用进展

Application progress of microfluidic chip in isolation and capture of circulating tumor cells

外周血中的循环肿瘤细胞(CTC)含量极少,分离比较困难。微流控芯片以便携性、灵敏度高、高捕获和成本低等特点正成为近年来不断发展的热点领域。微流控装置已被证明可以保持为CTC分离捕获提供最佳性能,包括通量、纯度、回收率和临床相关性。但目前微流控技术仍无法很好地实现高回收率和高纯度的回收CTC。

The amount of circulating tumor cells(CTC)in peripheral blood is very small,which is difficult to isolate.Microfluidic chips are becoming a hot area in recent years because of their portability,high sensitivity,high capture,and low cost.Microfluidic devices have been shown to maintain optimal performance for CTC isolation capture,including flux,purity,recovery,and clinical relevance.However,microfluidic technology is still unable to recover CTC with high recovery and purity.