不同糖代谢状态成年人血红蛋白与血尿酸的关联分析

Relationship between hemoglobin and serum uric acid in adults with various glucose metabolism status

目的探讨不同糖代谢状态成年人群血红蛋白与血尿酸的关联。方法收集2018年1月至2021年12月在解放军总医院第二医学中心进行健康体检的成年人群的人口学资料及生化指标,按血尿酸水平分为正常血尿酸和高尿酸血症2组,采用Pearson相关分析、logistic回归分析血红蛋白(按四分位分为Q1~Q44个亚层)与血尿酸的关联性,并分析年龄和糖代谢状态对血红蛋白与血尿酸关联的影响。结果共纳入研究对象33183名,年龄(50.6±10.0)岁。正常血尿酸组血红蛋白(142.61±14.24)g/L显著低于高尿酸血症组(151.79±11.24)g/L,差异有统计学意义(P<0.001)。单因素Pearson相关分析显示,血红蛋白与血尿酸呈正相关(r=0.444,P<0.001)。在调整相关混杂因素后,多因素logistic回归分析显示,血红蛋白与血尿酸之间存在关联,与血红蛋白Q1组相比,血红蛋白Q2~Q4组出现高尿酸血症的OR(95%CI)值分别为1.29(1.13~1.48)、1.42(1.24~1.62)和1.51(1.32~1.72),P_(趋势)<0.001;亚组和交互分析显示,随着血红蛋白升高,年龄<60岁、正常血糖、糖尿病前期的成年人血尿酸均随之升高(P_(趋势)<0.05,P_(交互)<0.001)。结论成年人血红蛋白与血尿酸关联受年龄和糖代谢状态的影响。

Objective To investigate the relationship between hemoglobin and serum uric acid in adults with various glucose metabolism status.Methods The demographic data and biochemical indicators of the adult population who had received physical examination in the Second Medical Center of the PLA General Hospital from January 2018 to December 2021 were collected.The subjects were divided into two groups according to the level of serum uric acid:the normal uric acid group and the hyperuricemia group.The relationship between hemoglobin(stratified into four levels of Q1 to Q4 by the quartile)and serum uric acid was quantified by using Pearson correlation and logistic regression analysis.The effects of age and glucose metabolism status on the relationship between hemoglobin and serum uric acid were analyzed.Results A total of 33183 adults were enrolled with age(50.6±10.0)years.The level of hemoglobin in the normal uric acid group(142.61±14.24)g/L was significantly lower than that in the hyperuricemia group[(151.79±11.24)g/L,P<0.001].Univariate Pearson correlation analysis showed that hemoglobin was positively associated with serum uric acid(r=0.444,P<0.001).After adjusting for related confounding factors,multivariate logistic regression analysis showed that hemoglobin was associated with serum uric acid,and the OR values(95%CI)of hemoglobin Q2 to Q4 group were 1.29(1.13-1.48),1.42(1.24-1.62)and 1.51(1.32-1.72),respectively(P_(trend)<0.001)when compared with hemoglobin Q1 group.Subgroup analysis and hierarchical interaction analysis suggested that with the increase of hemoglobin,the serum uric acid in the age<60 years subgroup,normal glucose subgroup and prediabetes subgroup increased gradually(P_(trend)<0.05 and P_(interaction)<0.001).Conclusion The association between hemoglobin and serum uric acid in adults is affected by age and glucose metabolism status.