妇科断红饮胶囊联合左炔诺孕酮治疗功能失调性子宫出血的临床研究

Clinical study on Fuke Duanhongyin Capsules combined with levonorgestrel in treatment of dysfunctional uterine bleeding

目的 探讨妇科断红饮胶囊联合左炔诺孕酮片治疗功能失调性子宫出血的临床疗效。方法 选取2018年4月—2021年5月华北医疗健康集团邢台总医院收治的110例功能失调性子宫出血患者,根据随机数字表法将所有患者分为对照组和治疗组,各为55例。对照组口服左炔诺孕酮片,1.5 mg/次,2次/d,待阴道停止流血3 d后,调整为0.75 mg/次,1次/d。治疗组在对照组的基础上口服妇科断红饮胶囊,3粒/次,3次/d。两组患者持续治疗2周。观察两组的临床疗效,比较两组的临床症状恢复情况、子宫内膜厚度、凝血功能指标和性激素指标。结果 治疗后,治疗组的总有效率为90.91%,高于对照组总有效率74.55%,组间比较有显著差异(P<0.05)。治疗后,治疗组的有效控制出血时间短于对照组,月经周期天数长于对照组,子宫内膜厚度小于对照组,月经失血图(PBAC)评分高于对照组(P<0.05)。治疗后,两组凝血活酶活性时间(APTT)、凝血酶时间(TT)均显著下降(P<0.05);治疗后,治疗组APTT、TT均明显小于对照组(P<0.05)。治疗后,两组血清卵泡刺激素(FSH)、孕酮(P)、催乳素(PRL)水平均显著降低(P<0.05);治疗后治疗组血清FSH、P、PRL水平明显低于对照组(P<0.05)。结论 妇科断红饮胶囊联合左炔诺孕酮片治疗功能失调性子宫出血具有较好的临床疗效,可有效减少出血,调节机体相关细胞因子分泌,安全可靠。

Objective To explore the clinical efficacy of Fuke Duanhongyin Capsules combined with Levonorgestrel Tablets in treatment of dysfunctional uterine bleeding. Methods Patients(110 cases) with dysfunctional uterine bleeding in Xingtai General Hospital of North China Medical Health Group from April 2018 to May 2021 were divided into control and treatment groups according to the random number table method, and each group had 55 cases. Patients in the control group were po administered with Levonorgestrel Tablets, 1.5 mg/time, twice daily, after vaginal bleeding stops for 3 days, adjust the dosage to 0.75 mg/time, once daily.Patients in the treatment group were po administered with Fuke Duanhongyin Capsules on the basis of the control group, 3 grains/time,three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the recovery of clinical symptoms, endometrial thickness, coagulation function indexes, and the sex hormone indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 90.91%, which was higher than that of the control group(74.55%), and there was a significant difference between two groups(P < 0.05). After treatment, the effective bleeding control time of the treatment group was shorter than that of the control group, the days of menstrual cycle of the treatment group was longer than that of the control group, the endometrial thickness of the treatment group was smaller than that of the control group, and the PBAC score of the treatment group was higher than that of the control group(P < 0.05). After treatment, APTT and TT in two groups were significantly decreased(P < 0.05), and APTT and TT in the treatment group were significantly lower than those in the control group(P < 0.05). After treatment, the serum levels of FSH, P, and PRL were significantly decreased in two groups(P < 0.05),and the serum levels of FSH, P, and PRL in the treatment group were significantly lower than those in the control group(P < 0.05).Conclusion Fuke Duanhongyin Capsules combined with Levonorgestrel Tablets has clinical curative effect in treatment of dysfunctional uterine bleeding, can effectively reduce bleeding and regulate secretion of related cytokines, which is safe and reliable.