槲皮素改善骨质疏松的作用机制研究进展

Research progress on mechanism of quercetin in improving osteoporosis

骨质疏松症是目前老龄化社会急需解决的慢性骨科疾病,是一种以骨量丧失、骨微结构恶化为特征的全身性骨骼疾病,因此如何有效地预防和治疗骨质疏松症越来越受到人们的关注。槲皮素是自然界广泛存在天然黄酮醇类化合物,具有雌激素样作用,可抑制骨吸收和促进骨形成。槲皮素通过抑制破骨细胞、调控骨髓间充质干细胞的细胞机制,促进骨形成、抑制骨吸收的信号通路机制,以及雌激素信号途径改善骨质疏松。综述了槲皮素改善骨质疏松的作用机制,希望为槲皮素的临床应用提供参考。

Osteoporosis is a chronic orthopedic disease urgently needed to be solved in the aging society, and it is a systemic bone disease characterized by bone loss and deterioration of bone microstructure, so how to effectively prevent and treat osteoporosis has attracted more and more attention. Quercetin is a natural flavonol compound widely existing in nature, and it has the effect of estrogen,and can inhibit bone resorption and promote bone formation. Quercetin can improve osteoporosis by inhibiting osteoclasts, regulating bone marrow mesenchymal stem cells, promoting bone formation, inhibiting bone resorption, and regulating estrogen signal pathway.This article reviews the mechanism of quercetin in improving osteoporosis, hoping to provide a reference for the clinical application of quercetin.