龙倍散神阙穴贴敷联合中药辨证口服治疗早泄的临床疗效分析

Clinical Efficacy of Longbeisan Application at Shenque(CV 8)Combined with Oral Administration of Chinese Medicine in Treatment of Premature Ejaculation

目的:探讨龙倍散神阙穴贴敷联合中药辨证口服对早泄(PE)的临床价值。方法:选取98例同期在河南中医药大学第一附属医院男科就诊的PE患者,随机分为观察组和对照组,每组49例,观察组采用龙倍散神阙穴贴敷联合中药辨证口服治疗,对照组采用盐酸达泊西汀片治疗,治疗8周。观察并对比2组患者阴道内射精潜伏期(IELT)、中国早泄患者性功能评价表-5(CIPE-5)评分、患者性生活满意度、配偶性生活满意度及有效率和不良事件发生率。结果:治疗结束后,观察组总有效率为85.71%(42/49),对照组总有效率为67.35%(33/49),观察组明显优于对照组,差异有统计学意义(χ^(2)=6.262,P<0.05)。与本组治疗前比较,两组患者IELT、CIPE-5评分、患者及配偶满意度评分均显著升高(P<0.01)。与对照组治疗后比较,观察组患者IELT、CIPE-5评分、患者及配偶满意度评分均明显升高(P<0.05,P<0.01)。观察组临床疗效优于对照组。治疗期间,对照组患者出现7例(7/49,14.29%)不良反应,观察组患者出现2例(2/49,4.08%)不良反应,观察组安全性优于对照组(χ^(2)=9.000,P<0.05)。随访评价中,对照组患者出现11例(11/49,22.45%)症状加重,治疗组患者出现3例(3/49,6.12%)症状加重,观察组具有更好的持久作用(χ^(2)=0.317,P<0.05)。结论:龙倍散神阙穴贴敷联合中药辨证口服治疗PE与盐酸达泊西汀相比,可以获得更好的临床效果,且具有更强的安全性和远期疗效。

Objective:To investigate the clinical value of Longbeisan application at Shenque(CV 8)combined with oral administration of Chinese medicine in the treatment of premature ejaculation(PE).Method:A total of 98 PE patients treated in the andrology department of the First Affiliated Hospital of Henan University of Chinese Medicine at the same time period were randomly assigned into an observation group and a control group,with 49 patients in each group.The observation group received Longbeisan application at Shenque(CV 8)combined with oral treatment of Chinese medicine according to syndrome differentiation,and the control group was treated with dapoxetine hydrochloride tablets.The treatment in both groups lasted for 8 weeks.The intravaginal ejaculatory latency time(IELT),Chinese index of premature ejaculation-5(CIPE-5)score,patient's sexual life satisfaction,spouse's sexual life satisfaction,effective rate,and adverse reaction incidence were compared between the two groups.Result:After treatment,the observation group had higher total effective rate than the control group[(85.71%(42/49)vs.67.35%(33/49),χ^(2)=6.262,P<0.05].The IELT,CIPE-5 score,and patient's and spouse's satisfaction scores after treatment increased compared with those before treatment(P<0.01),and the increases were more significant in the observation group(P<0.05,P<0.01).The clinical effect of the observation group was better than that of the control group.During the treatment,7(7/49,14.29%)patients in the control group and 2,2/49,4.08%)patients in the observation group showed adverse reactions,which indicated the safety of the observation group was better than that of the control group(χ^(2)=9.000,P<0.05).In the follow-up period,11(11/49,22.45%)patients in the control group and 3(3/49,6.12%)patients in the observation group showed aggravation of symptoms,which meant that the observation group had better lasting effect(χ^(2)=0.317,P<0.05).Conclusion:Longbeisan application at Shenque(CV 8)combined with oral administration of Chinese medicine has better clinical effect,stronger safety,and longer effect than dapoxetine hydrochloride in the treatment of PE.