肿瘤模型研究进展

Research progress of tumor models

肿瘤研究依赖肿瘤模型,经典的动物模型和细胞培养不能较好地模拟人类肿瘤特征。类器官模型、动物模型、微流控芯片模型和数学模型已经成为研究肿瘤生物特性和治疗反应的理想模型,它们为肿瘤研究提供有力的工具。然而新的肿瘤模型也呈现进化,计算机模型可能是未来肿瘤模型发展的方向。本文综述新的肿瘤模型在肿瘤临床和研究中的进展。

Cancer research relies on model systems,but animal models and cell cultures cannot preferably model human cancers characteristics.Organoids,xenografts,microfluidics,and mathematical modeling have produced better models for studying tumor biologic characteristics and treatment responses,these tumor models provide useful tools for cancer research.However,tumor models have also genomic evolution,and computer modelling will be future direction of tumor models.Here,we review the current state and future prospects of tumor models in cancer clinic and research.