ABCA1基因多态性与女性2型糖尿病患者心血管事件风险的研究

ABCA1 gene polymorphisms and cardiovascular event risk in Chinese Han female patients with diabetes mellitus

目的探讨女性2型糖尿病(type 2 diabetes mellitus,T2DM)患者中ABCA1 rs2230806(A>G)基因多态性与心血管事件风险的相关性。方法利用TaqMan SNP基因分型分析年龄18~75岁的196例女性2型糖尿病患者及90例女性健康志愿者rs2230806基因多态性,进行卡方检验和多变量逻辑回归分析,评估女性rs2230806与糖尿病易感性之间的关联。结果GG基因型与女性2型糖尿病低风险之间存在显着相关性(P=0.015)。在加性模型中,GG较AA、AG基因型的糖尿病风险显著降低(P=0.016)。在阴性模型中,GG较AA+AG基因型的女性2型糖尿病风险显著降低(P=0.007)。结论ABCA1 rs2230806多态性G等位基因与女性糖尿病发病风险及心血管事件的发生率具有负相关性。

Objective To investigate the correlation between gene polymorphisms of ABCA1 rs2230806(A>G)and cardiovascular event risk in female patients with type 2 diabetes mellitus(T2DM).Methods The female patients with type 2 diabetes mellitus(T2DM,n=196,age 18~75 years old)and female healthy volunteers(n=90,age 18~75 years old)were given an analysis on gene polymorphisms of ABCA1 rs2230806 by using TaqMan SNP genotyping.The correlation between ABCA1 rs2230806 gene polymorphisms and female T2DM susceptibility was reviewed by using chi-square test and multivariate Logistic regression analysis.Results There was a significant correlation between GG genotype and low risk of female T2DM(P=0.015).In additive model,the risk of female T2DM decreased significantly in GG genotype compared with AA and AG genotypes(P=0.016).In negative model,the risk of DM decreased significantly in GG genotype compared with AA+AG genotype(P=0.007).Conclusion The G allele of ABCA1 rs2230806 gene polymorphisms is negatively correlated to DM risk and incidence rates of cardiovascular events in female patients.