摘要
覆盆子酮是蔷薇科多年生木本植物覆盆子的主要功效成分之一,具有血糖改善、养肝明目、抑菌抗癌和益肾减肥等卓越功效。随着覆盆子酮现有功效被大众不断认可及其更多的功效被科学家发现,其市场需求量与日俱增,而目前鲜有覆盆子酮工业化制备方法的公开报道。本文以苯酚为起始原料,4-氯-2-丁酮为原料和溶剂,在无水三氯化铝作用下进行傅克烷基化反应,一步法制得覆盆子酮,未参与反应的原料除了正常损耗外均能回收,用于下一批次制备工序。另外,创新地引入熔融结晶技术对覆盆子酮进行深度纯化,可制得HPLC纯度达到99.95%的高纯品,能广泛运用于食品、化妆品等领域。所述覆盆子酮制备技术成本较低,产品品质极好,非常适合工业化量产,有助于促进后疫情时代地方经济恢复增长。
Raspberry ketone is one of the main functional components of the perennial woody plant raspberry of Rosaceae,which can lower blood sugar,nourish the liver and eyes,inhibit bacteria and cancer,and benefit the kidney and lose weight.As the existing efficacy of raspberry ketone is continuously recognized by the public and more efficacy is discovered by scientists,the market demand for raspberry ketone is increasingly growing.At present,there are few public reports on the industrialized preparation methods of raspberry ketone.With phenol as the starting material,4-chloro-2-butanone as the raw material and solvent,the raspberry ketone was prepared by one-step Friedel Crafts alkylation reaction under the action of anhydrous aluminum chloride.The raw materials not involved in the reaction can be recycled for the next batch preparation process except for normal loss.In addition,the melting crystallization technology was innovatively introduced to deeply purify raspberry ketone,which can produce a high-purity product with an HPLC purity of 99.95%,and can be widely used in food,cosmetics and other fields.The raspberry ketone preparation technology has low cost,excellent product quality,very suitable for industrial mass production,which is of great significance in promoting local economic recovery and growth in the post COVID-19 era.
作者
林韦康
康乐
陈艳欣
王景文
任会丹
张雷
陶春霖
宋延春
江晓明
曹晓琴
钱程良
王靖云
LIN Wei-kang;KANG Le;CHEN Yan-xin;WANG Jing-wen;REN Hui-dan;ZHANG Lei;TAO Chun-lin;SONG Yan-chun;JIANG Xiao-ming;CAO Xiao-qin;QIAN Cheng-liang;WANG Jing-yun(Wangshuhe Biomedicine(Wuhan)Co.,Ltd.,Wuhan,Hubei 430040,China;Henan University of Chinese Medicine,Zhengzhou,Henan 450046,China;Young Beauty(Shanghai)Network Technology Co.,Ltd.,Shanghai 201106,China;Suqian Chenyang Pharmaceutical Technology Co.,Ltd.,Suqian,Jiangsu 223800,China;Zhejiang Yuntao Biotechnology Co.,Ltd.,Shaoxing,Zhejiang 312369,China)
出处
《浙江化工》
CAS
2023年第4期15-22,30,共9页
Zhejiang Chemical Industry
关键词
覆盆子酮
抗衰老
抗癌
抑菌
功效原料
傅克烷基化
raspberry ketone
anti-aging
anticancer
bacteriostasis
functional raw materials
Foucault alkylation