“健脾补肺法”治反复呼吸道感染的疗效及对患儿免疫功能的影响

Effect of"invigorating the spleen and supplementing the lung"in treating repeated respiratory tract infection and its influence on the immune function of children

目的观察“健脾补肺法”治反复呼吸道感染的疗效及对患儿免疫功能的影响。方法前瞻性选取150例珠海市中西医结合医院2021年7月至2021年12月门诊收治的1~6岁反复呼吸道感染缓解期患儿为对象,采用简单随机法分为3组。A组50例给予口服健脾补肺颗粒联合推拿治疗,B组50例给予健脾补肺颗粒治疗,C组50例给予脾氨肽冻干粉口服治疗,连续服用8周。比较3组临床疗效、RRTI病情分级量表及体液免疫、细胞免疫功能差异。结果随访12个月,发现A组总有效率为96.00%,其次为B组的84.00%,最低为C组的76.00%,A组总有效率高于B、C组,差异有统计学意义(P<0.05)。治疗6、12个月后,3组平均每月发作次数、单次发作病程、病种评分均较治疗前下降,且A组低于B、C组,B组低于C组,差异均有统计学意义(P<0.05)。治疗6、12个月后,3组IgA、IgM、IgG、CD4^(+)、CD4^(+)/CD8^(+)均较治疗前升高,CD8^(+)较治疗前下降,且A组体液免疫、细胞免疫指标优于B、C组,B组优于C组,差异均有统计学意义(P<0.05)。结论从“健脾补肺法”治疗反复呼吸道感染患儿可有效减少复发,提高疗效,其机制可能与改善体液免疫和细胞免疫有关。

Objective To observe the therapeutic effect of"invigorating the spleen and invigorating the lung"on recurrent respiratory tract infection and its influence on the immune function of children.Methods A total of 150 children aged 1 to 6 years in remission of recurrent respiratory tract infection admitted to the outpatient department of Zhuhai Integrated Traditional Chinese and Western Medicine Hospital from July 2021 to December 2021 were prospectively selected and divided into three groups by simple random method.50 cases in group A were given oral Jianpi Bufei granules combined massage therapy;50 cases in group B were given oral Jianpi Bufei granules;50 cases in group C were given lyophilized spleen ammonia peptide powder for consecutive 8 weeks.The clinical efficacy,RRTI disease grading scale,humoral immunity and cellular immunity of the three groups were compared.Results After 12 months of follow-up,it was found that the total effective rate of group A was 96.00%,followed by 84.00%of group B,and the lowest was 76.00%of group C.After statistical test,it was found that the total effective rate of group A was higher than the other two groups,the differences were statistically significant(P<0.05).After 6 months and 12 months of treatment,the average number of attacks per month,duration of single attack and disease type score in the three groups decreased compared with those before treatment,and group A was lower than those in the group B,group C,while group B was lower than group C,the differences were statistically significant(P<0.05).After 6 and 12 months of treatment,IgA,IgM,IgG,CD4^(+),CD4^(+)/CD8^(+)in the three groups were higher than before treatment,while CD8^(+)was lower than before treatment,moreover,the indexes of humoral immunity and cellular immunity in group A were better than those in the group B,group C,and those in group B were better than those in group C,the differences were statistically significant(P<0.05).Conclusion The treatment of recurrent respiratory tract infection by"invigorating the spleen and invigorating the lung"can effectively reduce the recurrence and improve the curative effect.The mechanism may be related to the improvement of humoral immunity and cellular immunity.