厚朴排气合剂联合经皮穴位电刺激对膝关节单髁置换术后胃肠功能恢复的影响

The Influence of Officinal Magnolia Bark Exhaust Mixture Combined with Transcutaneous Electrical Stimulation of Acupoints on Gastrointestinal Function Recovery After Unilateral Condylar Replacement of Knee Joint

目的:观察厚朴排气合剂联合经皮穴位电刺激对膝关节单髁置换术后胃肠功能恢复的影响。方法:将88例行膝关节单髁置换术患者按照随机数字表法分为对照组和观察组,每组各44例。对照组术后给予厚朴排气合剂治疗,观察组在对照组治疗的基础上联合经皮穴位电刺激治疗。比较两组患者的临床疗效、胃肠功能恢复时间及治疗前后临床症状评分、血清胃动素、胃泌素、白细胞介素(interleukin,IL)-2、IL-6水平、血清miR-10b-5p,miR-155相对表达量变化情况。结果:观察组有效率86.36%,对照组有效率68.18%,两组患者有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后临床症状评分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组肠鸣音恢复时间、肛门排气及排便时间短于对照组,差异具有统计学意义(P<0.05)。两组患者治疗治疗后胃动素、胃泌素、IL-2、IL-6水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后miR-155水平低于本组治疗前,miR-10b-5p水平高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。结论:厚朴排气合剂联合经皮穴位电刺激可缩短膝关节单髁置换术后患者胃肠功能的恢复时间,改善患者临床症状,降低血清炎症因子水平,增加血清miR-10b-5p表达,降低血清miR-155相对表达量,促进肠胃蠕动,恢复肠胃功能。

Objective:To observe the influence of Officinal Magnolia Bark Exhaust Mixture combined with transcutaneous electrical stimulation of acupoints on gastrointestinal function recovery after unilateral condylar replacement of knee joint.Methods:A total of 88 patients with unilateral condylar replacement of knee joint were randomly divided into the control group and the observation group,with 44 cases in each group.The control group was treated with Officinal Magnolia Bark Exhaust Mixture after operation,while the observation group was treated with transcutaneous acupoint electrical stimulation on the basis of the control group.The clinical efficacy,recovery time of gastrointestinal function,the changes of clinical symptom score,levels of motilin,gastrin,interleukin-2,IL-6,serum miR-10b-5p,and relative expression of miR-155 were compared between the two groups before and after treatment.Results:The effective rate of the observation group was 86.36%,while that of the control group was 68.18%.The difference between the two groups was statistically significant(P<0.05).The clinical symptom scores of the two groups after treatment were lower than those before treatment,and the score of the observation group after treatment were lower than that of the control group.The difference between the two groups was statistically significant with a statistically significant difference(P<0.05).The recovery time of bowel sounds,anal exhaust and defecation in the observation group was shorter than that in the control group,with statistically significant differences(P<0.05).After treatment,the levels of motilin,gastrin,IL-2 and IL-6 in the two groups were lower than those before treatment,and the above levels in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the level of miR-155 in the two groups was lower than that before treatment,and the level of miR-10b-5p was higher than that before treatment.The differences between the two groups were statistically significant(P<0.05).Conclusion:Officinal Magnolia Bark Exhaust Mixture combined with percutaneous electrical stimulation of acupoints can shorten the recovery time of gastrointestinal function of patients after unilateral condylar replacement of knee joint,improve the clinical symptoms of patients,reduce the level of serum inflammatory factors,increase the expression of serum miR-10b-5p,reduce the relative expression of serum miR-155,promote gastrointestinal peristalsis,and restore gastrointestinal function.