脉络舒通丸联合常规西药治疗骨科术后并发下肢血栓性浅静脉炎患者的回顾性分析

Retrospective Analysis of Mailuo Shutong Pills Combined with Conventional Western Medicine in the Treatment of Patients with Lower Extremity Superficial Thrombophlebitis after Orthopedic Surgery

目的:回顾性分析骨科术后并发下肢血栓性浅静脉炎的患者,采用脉络舒通丸联合常规西药治疗观察血液流变学、血管内皮功能、临床症状评分等指标影响。方法:选取2019年5月至2021年10月在黑龙江中医药大学附属第一医院接受骨科手术治疗后并发下肢血栓性浅静脉炎患者150例作为研究对象,根据用药方案分为对照组(n=67)和观察组(n=83),对照组采用常规西药治疗,观察组在常规治疗的基础上加用脉络舒通丸,比较2组患者血液流变学、血管内皮功能、临床症状评分等指标。结果:治疗前2组患者血液流变学、血管内皮功能、临床症状评分比较,差异无统计学意义(P>0.05),治疗后观察组血浆黏度、红细胞沉降率、纤维蛋白、内皮素-1(ET-1)、血栓素B_(2)(TXB_(2))水平及临床症状评分均低于对照组(P<0.01),一氧化氮(NO)、血管内皮生长因子(VEGF)水平及临床总有效率均高于对照组,差异有统计学意义(P<0.05或P<0.01)。结论:对骨科术后并发下肢血栓性浅静脉炎的患者,在常规西药治疗的基础上联合脉络舒通丸治疗,可有效维持血液流变学指标水平稳定,保护血管内皮细胞,缓解患者的各项症状。

Objective:To retrospectively analyze the effects of Mailuo Shutong Pills combined with conventional western medicine on hemorheology,vascular endothelial function,clinical symptom score,and other indicators in the treatment of patients with lower extremity superficial thrombophlebitis after orthopedic surgery.Methods:A total of 150 patients with superficial thrombophlebitis of lower extremity after orthopedic surgery treated in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2019 to October 2021 were enrolled and divided into a control group(n=67)and an observation group(n=83).All patients were treated with conventional western medicine,while those in the observation group received additional Mailuo Shutong Pills.The hemorheology,vascular endothelial function,and clinical symptom score were compared between the two groups.Results:There were no significant differences in hemorheology,vascular endothelial function,and clinical symptom score between the two groups before treatment(P>0.05).The levels of plasma viscosity,erythrocyte sedimentation rate,fibrin,endothelin-1(ET-1),thromboxane B_(2)(TXB_(2)),and clinical symptom score in the observation group were lower than those in the control group after treatment(P<0.01),and the levels of nitric oxide(NO),vascular endothelial growth factor(VEGF),and total clinical effective rate were higher than those in the control group(P<0.05 or P<0.01).Conclusion:For patients with lower extremity superficial thrombophlebitis after orthopedic surgery,Mailuo Shutong Pills combined with conventional western medicine can effectively maintain the stability of hemorheological indexes,protect vascular endothelial cells,and relieve the symptoms of patients.