肠道菌群及联用组学技术在中药领域上的研究进展

Advances in the Application of Intestinal Flora and Multi-omics in Traditional Chinese Medicine

肠道菌群与各脏器相关联,能够反映中医药整体观特点。肠道菌群在中药作用机制、配伍应用和毒理等领域广泛应用。中药可影响肠道菌群数量和组成,改善肠菌丰度和多样性,同时肠道菌群也可代谢转化中药活性成分,与中药相互影响,促进中药药效发挥。肠道菌群联合代谢组学等多组学技术通过多层次分析,有利于全面阐释肠道菌群与中药作用机制。本文利用数据库综合检索近十年发表的相关文献,阐释肠道菌群和中药之间的相互作用,归纳总结肠道菌群在中药药效、配伍、炮制、毒理领域的研究进展以及与代谢组学等多组学技术联合应用,为深入研究肠道菌群和中药之间的关系及多组学技术在肠道菌群与中药之间的应用提供理论依据和参考。

Intestinal flora associated with a variety of organs may reflect the holistic view of traditional Chinese medicine(TCM).Intestinal flora has been concerned in a wide range of studies involving the mechanism,compatibility,and toxicology of Chinese medicines.Chinese medicines can regulate the number and composition and improve the abundance and diversity of intestinal flora.Moreover,intestinal flora can metabolize and transform the active ingredients in Chinese medicines to improve the efficacy of Chinese medicines.Multi-omics including metabolomics can help to fully explain the interaction mechanisms between intestinal flora and Chinese medicines through multi-level analysis.We reviewed the relevant articles published in the last decade to explain the interactions between intestinal flora and Chinese medicines.The progress in the research on intestinal flora in the fields of efficacy,compatibility,processing,and toxicology of Chinese medicines and the application of multi-omics was summarized.This review aims to provide a theoretical basis for further research on the relationship between intestinal flora and Chinese medicine and the application of multi-omics in this research field.