抗肿瘤药物诱导脱发的相关性研究进展

Research Progress on the Correlation of Antitumor Drug Induced Alopecia

脱发是肿瘤患者常见的不良反应之一。抗肿瘤药物包括细胞毒性化疗药物、靶向药物、免疫检查点抑制剂和内分泌药物等,均可不同程度地诱导患者脱发。虽然脱发不会危及患者生命,与其他药物不良反应相比,脱发也往往被医师所忽视,但是脱发对患者外在形象、性取向及自尊心等均有影响,有些患者甚至还会出现焦虑或抑郁现象,导致他们的生活质量进一步降低。因此本文对抗肿瘤药物导致脱发的相关文献进行综述,以期为肿瘤患者脱发提供临床参考价值。

Alopecia is probably one of the common adverse reactions for oncological patients.Antineoplastic drugs,including cytotoxic chemotherapy drugs,targeted agents,immune checkpoint inhibitors and endocrine drugs could induce alopecia to varying degrees.Although hair loss is not life-threatening,and it is often underestimated by physicians compared to other adverse drug reactions.But it negatively influences body image,sexuality and self-esteem.Even some patients experienced anxiety or depression,which further reduced their quality of life.Therefore,this article reviews the literature related to hair loss caused by anti-tumor drugs,in order to provide clinical reference value for cancer patients with hair loss.