肠道免疫细胞通过肠-肝轴调控脂肪性肝病的研究进展

The role of intestinal immune cells in regulation of fatty liver disease progress through gut-liver axis

脂肪性肝疾病是全球范围内常见的慢性肝病之一,而肠-肝轴在脂肪性肝病中的作用日益凸显。肠道功能紊乱会影响肝脏疾病的发生或发展,其中肠道免疫细胞在肝病的发生发展中也扮演着重要角色。大量研究表明肠道中的巨噬细胞、淋巴细胞、树突状细胞(DC)等免疫细胞以及它们的亚群可通过肠-肝轴途径的不同机制影响脂肪肝病的进展,包括调控肠道屏障功能、肠道脂质转运体功能以及免疫细胞直接迁移至肝脏等。

Fatty liver disease is one of the most prevalent chronic liver disease worldwide and the gut-liver axis is recognized as increasingly prominent in fatty liver disease.Intestinal dysfunction can affect the occurrence or progression of liver disease,therein,validating the critical role of the intestinal immune cells.Enormous literature reported that macrophages,lymphocyte,dendritic cells(DCs)and other immune cells in the gut as well as their subsets may regulate the fatty liver disease progression via different mechanisms,including disruption of intestinal barrier,dysregulation of intestinal lipid transporters and mediating immune cell migration to liver.