系统性红斑狼疮复发的影响因素研究进展

Influencing factors of recurrence of systemic lupus erythematosus:An update

系统性红斑狼疮(SLE)是一种累及多个组织器官的慢性自身免疫性疾病,反复发作是SLE诊治中面临的主要问题之一,疾病复发通常没有明确的原因。我们总结了SLE患者的生存现状和复发情况,并着重从遗传因素、环境因素(感染、紫外线、维生素D、化工污染物)、药物及患者依从性、系统损害及疾病状态、性激素与妊娠、社会心理方面归纳复发机制及研究进展,以期实现临床尽早预防,达到疾病长期、有效缓解,改善患者的生存质量。

Systemic lupus erythematosus(SLE)is a chronic autoimmune disease involving multiple tissues and organs.Frequent flare has been regarded as one of the main problems in the diagnosis and treatment of SLE,while the causes for frequent flare has remained to be unclear.We summarized the survival status and the situation of recurrence of SLE patients.The research progress regarding the recurrence and its mechanism will be reviewed from the aspects of genetic factors,environmental factors(i.e.infection,ultraviolet,vitamin D,chemical pollutants),drug and patient compliance,systemic damage and disease status,sex hormones and pregnancy,and social psychology.The implication is to explore effective clinical intervention to alleviate the SLE disease and improve the living quality of the patients.