外泌体在肿瘤诊疗中的研究进展

Research Progress of Exosomes in Tumor Diagnosis and Treatment

综述外泌体调控各类型肿瘤生物学行为特性,介绍外泌体在肿瘤诊疗中的研究进展,为外泌体在肿瘤精准诊疗领域中的应用提供理论依据.结果表明:外泌体广泛分布于肿瘤患者的血浆、尿液、唾液等各种体液中,来源于外泌体的核酸、蛋白质可介导不同类型肿瘤的生物学行为,在人体内的表达异常或可作为肿瘤早期诊断和预后评估的潜在生物标志物;对外泌体进行加工修饰后,产物可用于肿瘤疫苗制备和靶向药物研发.

In order to provide theoretical basis for the application of exosomes in the field of precise diagnosis and treatment of tumors,the regulation of exosomes on the biological behavior of each type of tumors is summarized,and the research progress of exosomes in tumor diagnosis and treatment is introduced.The results show that exosomes are widely distributed in each kind of fluid of tumor patients,such as plasma,urine,and saliva.Nucleic acids and proteins from exosomes can mediate the biological behavior of different type tumors,and their abnormal expression in humans may be used as potential biomarkers for early diagnosis and prognosis evaluation of tumors.After processing and modifying the exosomes,the product can be used for tumor vaccine preparation and targeted drug research and development.