火针密刺法联合中药熏蒸治疗瘀血阻络型膝骨性关节炎患者的临床疗效观察

Clinical Observation of Dense Fire Needling Combined with Chinese MedicinalFumigation in Treating KOA of Blood Stasis Blocking Collateral Type

目的:探究火针密刺法联合中药熏蒸治疗瘀血阻络型膝骨性关节炎患者的疗效。方法:选取2020年1月—2022年1月江阴市中医院接诊的膝骨性关节炎患者120例,采用随机数字表法分为研究组和对照组,每组60例,对照组患者采用中药熏蒸治疗,研究组采用中药熏蒸联合火针密刺法治疗。治疗1个月后,比较两组的中医证候积分、血清基质金属蛋白酶-3(MMP-3)和软骨寡聚基质蛋白(COMP)水平、关节炎症指数评分(WOMAC)、临床疗效及不良反应。结果:治疗后1个月,研究组有效率为93.33%(56/60),高于对照组的80.00%(48/60),差异有统计学意义(P<0.05)。研究组治疗后主症积分、次症积分、WOMAC评分、血清MMP-3、COMP水平均低于对照组(P<0.05)。研究组治疗期间不良反应发生率为5%(3/60),与对照组的0%(0/60)比较,差异无统计学意义(P>0.05)。结论:火针密刺法联合中药熏蒸治疗瘀血阻络型膝骨性关节炎,更有助于保护患者膝关节软骨功能,临床疗效优越且安全性良好。

Objective:To explore the curative effect of dense fire needling combined with Chinese medicinal fumigation in treatment of knee osteoarthritis(KOA)of blood stasis blocking collateral type.Methods:120 patients with KOA were randomly divided into the study group and the control group,with 60 patients in each group.The control group was treated with Chinese medicinal fumigation;on which basis,the study group was also treated with dense fire needling.After one month of treatment,the TCM symptom scores,the serum levels of matrix metalloproteinase-3(MMP-3)and cartilage oligomeric matrix protein(COMP),the score of Western Ontario and McMaster Univeristy Arthritis Index(WOMAC),the clinical efficacy and adverse reactions were compared between the two groups after one month of treatment.Results:The effective rate was 93.33%(56/60)in the study group,which was significantly higher than 80.00%(48/60)in the control group(P<0.05).The main symptom score,secondary symptom score and WOMAC score,as well as the serum levels of MMP-3 and COMP were lower in the study group than those in the control group(P<0.05).The incidence of adverse reactions was 5%(3/60)in the study group during the treatment,and it was 0%(0/60)in the control group;in which there was no statistical difference between the two groups(P>0.05).Conclusion:The combination of dense fire needling and Chinese medicinal fumigation is more beneficial to protect the cartilage function of the patients’knee joint in treatment of KOA of blood stasis blocking collateral type,with superior clinical efficacy and good safety.