拓扑异构酶抑制剂伊立替康的研究进展

Research Progress of Topoisomerase Inhibitor Irinotecan

抗肿瘤药伊立替康(Irinotecan,CPT-11)是一种喜树碱类衍生物,主要通过抑制拓扑异构酶I来实现细胞毒作用,目前已用于治疗各种恶性肿瘤多年。尽管如此,关于这种药物的知识正仍在扩大。在这里,本文对伊立替康的作用机制、代谢和毒副作用、与其他抗癌药物的联合应用以及药物的新剂型进行了全面的概述,以期为该药在临床的安全合理应用提供参考。

Antitumor drug irinotecan,a camptothecin derivative,has been used for many years to treat a variety of malignancies,mainly by inhibiting topoisomerase I to achieve cytotoxicity.Still,knowledge about the drug is growing.Here,the mechanism of action,metabolism and toxicity of irinotecan,its combination with other anticancer drugs and new dosage forms of irinotecan are reviewed,in order to provide a reference for the safe and rational clinical application of the drug.