免疫炎性细胞与肝癌发生、发展及预后的关系

Correlation of immune inflammatory index with occurrence,development and prognosis of hepatocellular carcinoma

肝癌为典型的慢性炎症相关恶性肿瘤,因慢性炎症持续破坏肝脏的网状内皮系统而导致免疫监视功能受损,进而免疫环境失调。机体监察系统受损而导致的免疫逃逸可提高肿瘤的免疫原性,在肿瘤的发生、发展中发挥重要作用。研究表明结合中性粒细胞、淋巴细胞、血小板等免疫炎性细胞的指标能够对肝癌的预后进行预测,以此为依据对患者进行的个体化治疗、早期干预治疗有望改善患者预后。文章介绍了免疫细胞在肝癌发生、发展中的作用,并归纳了近年来有关外周血免疫炎症指标与肝癌预后的关系。

Hepatocellular carcinoma is a typical chronic inflammatory-associated malignancy.Chronic inflammation continuously damages the reticuloendothelial system of the liver and leads to impairment of immune surveillance,which in turn leads to dysregulation of the immune environment.Immune escape caused by impaired surveillance system can improve the immunogenicity of tumor,which plays an important role in the occurrence and development of tumors.Studies have shown that the indicators including immune inflammatory cells such as neutrophils,platelets and lymphocytes can predict the prognosis of hepatocellular carcinoma,the individualized treatment and early intervention for patients on this basis is expected to improve the prognosis of patients.The article introduces the role of immune cells in the occurrence and development of hepatocellular carcinoma,and summarizes the relationship between peripheral blood immune inflammatory indicators and prognosis of hepatocellular carcinoma.