早产儿维生素D与心脑肺发育关系的研究进展

Research progress on the relationship between vitamin D and heart,brain and lung development in preterm infants

维生素D代谢是复杂的,目前妊娠期妇女维生素D缺乏的概率还比较高,这正成为一个较热的研究领域。维生素D在胎盘的转运主要发生在妊娠晚期,因而早产儿维生素D缺乏的概率更高。而早产儿心脑肺功能本身发育不成熟,既往研究维生素D与钙、磷及代谢性骨病的关系较多,最近的大鼠研究表明母体维生素D缺乏导致心肌细胞、神经细胞及肺泡上皮细胞出现改变。本综述旨在探讨维生D与心脑肺疾病的关系,以期为早产儿心脑肺疾病的防治提供新思路。

Vitamin D metabolism is complicated,and the probability of vitamin D deficiency in pregnant women is still relatively high,which is becoming a hot research area.The transfer of vitamin D in the placenta occurs mainly during the third trimester of pregnancy,so premature infants are at higher risk of vitamin D deficiency.However,the heart,brain and lung functions of preterm infants are not mature.There are many previous studies on the association of vitamin D with calcium,phosphorus and metabolic bone diseases.Recent rat studies have shown that maternal vitamin D deficiency leads to changes in cardiomyocytes,nerve cells and alveolar epithelial cells.This review aims to explore the relationship between vitamin D and heart,brain and lung diseases,in order to provide new ideas for the prevention and treatment of heart,brain and lung diseases in premature infants.