不同条件下大剂量紫檀芪对纳米乳液特性的影响

Effect of High Doses of Pterostilbene on the Properties of Nanoemulsion under Different Conditions

为了考察大剂量紫檀芪(Pterostilbene,PTE)对纳米乳液特性的影响,本研究构建了富含大剂量PTE的纳米乳液运载体系,同时研究了不同条件(包括pH、盐离子浓度、反复冻融、冻干、离心)PTE对乳液体系的粒径以及流变特性变化的影响。结果表明,大剂量PTE(2%,w/v)使乳液体系的粒径减小、ζ-电位绝对值增加、乳液黏度增加。在2000~8000r/min的中低离心转速下,大剂量PTE能显著(P<0.05)提高乳液的离心保留率;在不同pH、低盐离子浓度、冻干的处理条件下,大剂量PTE提高乳液体系稳定性。总之,纳米乳液体系对活性物质PTE的负载并不仅产生单向的影响,PTE本身就会影响乳液体系的构建和稳定性,该研究结果为拓展负载功能活性物质的乳液体系的应用提供了理论基础。

In order to investigate the effect of a high dose of pterostilbene(PTE)on the properties of nanoemulsion,a nanoemulsion delivery system enriched with a high dose of PTE was constructed,and the effect of PTE on the particle size and rheological properties of the emulsion system under different conditions(including pH,salt ion concentration,repeated freeze-thawing,freeze-drying and centrifugation)was investigated.The results showed that a high dose of PTE(2%,w/v)decreased the particle size,increased the absolute value ofζ-potential,the viscosity of the emulsions and the retention rate of the emulsions by centrifugation at 2000~8000 r/min.The high dose of PTE also improved the stability of the nanoe-mulsion under different pH,low salt ion concentration and freeze-drying treatment conditions.In conclusion,the nanoemulsion not only had a unidirectional effect on the loading of active substance such as PTE,but also the PTE itself affected the nanoemulsion construction and stability.This research would provide a theoretical basis for expanding the application of nanoemulsion loaded with active substances.