双酚类化合物对机体影响的研究进展

Research Progress on the Effects of Bisphenol Compounds on Human Beings and Animals

双酚类化合物(Bisphenol compounds,BPs)是合成高分子材料的重要原材料之一。目前,常见的双酚类化合物主要包括双酚A、双酚B、双酚F以及双酚AF等。现如今,双酚类化合物主要应用于塑料制品、食品包装、饮用水添加剂、海鲜等方面。大量的研究发现,双酚类化合物通过物理迁移、化学迁移、生物迁移途径侵入人类和动物体内,甚至在深海哺乳动物体内也检测到了该物质,从而影响了机体的生殖系统、神经系统、消化系统、心血管系统、行为、发育和代谢性疾病的发生发展。因此,双酚类化合物引起了更多的关注。因此,本文主要从BPs的分类、侵入机体的途径以及对机体的影响方面进行了综述,以期对BPs的进一步研究以及安全性和毒理学评价提供参考依据。

Bisphenol compounds(BPs)are one of the most significant raw materials,used in synthesizing high polymer materials.At present,common BPs mainly include bisphenol A,bisphenol B,bisphenol F,bisphenol AF and so on.Nowadays,BPs are principally applied in plastic products,the food packaging,drinking water additives,seafood and other fields.A large number of studies have found that BPs penetrate into human beings and animals by physical migration,chemical migration,biological migration and it even have been detected in deep-sea mammals,affecting the mechanisms of the reproductive system,central nervous system,digestive system,cardiovascular system,behavior,development,and metabolic diseases.Therefore,BPs have been attracting more attention.In the review,the classification,invasive pathway to foods of BPs,and its implication on human beings and animals are systematically reviewed,hoping to provide reference for the safety and toxicological evaluation of BPs.