摘要
BACKGROUND Multiple studies investigating the relationship between intake of different types of fruit and colorectal cancer(CRC)risk have yielded inconsistent results.AIM To perform a meta-analysis of existing studies to assess the association between the intake of different kinds of fruit and the incidence of CRC.METHODS We searched online literature databases including PubMed,Embase,WOS,and Cochrane Library for relevant articles available up to August 2022.With data extracted from observational studies,odds ratios(ORs)with 95%confidence intervals(CIs)were assessed using random-effects models.A funnel plot and Egger’s test were used to determine publication bias.Furthermore,subgroup analysis and dose-response analysis were performed.All analyses were conducted using R(version 4.1.3).RESULTS Twenty-four eligible studies involving 1068158 participants were included in this review.The meta-analysis showed that compared to a low intake,a higher intake of citrus,apples,watermelon,and kiwi reduced the risk of CRC by 9%[OR(95%CI)=0.91(0.85-0.97)],25%[OR(95%CI)=0.75(0.66-0.85)],26%[OR(95%CI)=0.74(0.58-0.94)],13%[OR(95%CI)=0.87(0.78-0.96)],respectively.No significant association was observed between the intake of other types of fruit and the risk of CRC.In the dose-response analysis,a nonlinear association was found[R(95%CI)=-0.0031(-0.0047 to-0.0014)]between citrus intake and CRC risk(P<0.001),with the risk minimized around 120 g/d(OR=0.85),while no significant dose-response correlation was observed after continued increase in intake.CONCLUSION We found that a higher intake of citrus,apples,watermelon,and kiwi was negatively associated with the risk of CRC,while the intake of other types of fruits were not significantly associated with CRC.Citrus intake showed a non-linear dose-response relationship with the risk of CRC.This meta-analysis provides further evidence that a higher intake of specific types of fruit is effective in preventing the occurrence of CRC.
