SERS and EC dual-mode detection for dopamine based on WO_(3)-SnO_(2)nanoflake arrays

As an important neurotransmitter,the detection of dopamine(DA)is of great significance for the diagnosis and treatment of neurological diseases.In this study,WO_(3)-SnO_(2)nanoflake arrays were synthesized on fluorine-doped tin oxide(FTO)by hydrothermal synthesis and pulse electrodeposition,revealing significant surface-enhanced Raman scattering(SERS)activity with an enhancement factor(EF)reaching 4.79×10^(7).The obvious EF was mainly ascribed to the charge transfer between WO_(3)-SnO_(2)and methylene blue(MB)based on chemical mechanism(CM)and the molecular resonance effect.With the competitive adsorption of DA and absorbed MB,we prepared a SERS and electrochemical(EC)dual-mode detection platform of DA based on the WO_(3)-SnO_(2)nanoflake arrays.The linear range(LR)was 5.00-1.75×10^(3)nmol/L,and the detection limits(LODs)were as low as 1.50 and 0.80 nmol/L by SERS and EC respectively.Besides,the developed detection platform can shield the interference of many neurotransmitters similar to DA,showing good selectivity and excellent stability.In general,the SERS-EC dual-mode detection platform can be well applied to the detection of DA in cell lysate,demonstrating great potential in diagnosis of neurodegenerative diseases.