T细胞糖酵解代谢在口腔扁平苔藓中的研究进展

Research progress on T cell glycolytic metabolism in oral lichen planus

口腔扁平苔藓(oral lichen planus,OLP)是口腔黏膜的一种慢性炎症性疾病,发病机制尚不明确,T细胞及相关细胞因子介导的免疫异常在OLP的发病过程中起着至关重要的作用。近年来糖酵解代谢相关转运蛋白、酶及调节因子,如葡萄糖转运蛋白1(glucose transporter 1,Glut1)、甘油醛3⁃磷酸脱氢酶(glyceraldehyde⁃3⁃phosphate dehydrogenase,GAPDH)、乳酸脱氢酶A(lactate dehydrogenase A,LDHA)、哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)和缺氧诱导因子⁃1α(hypoxia inducible factor⁃1α,HIF⁃1a),通过调控T细胞的增殖、分化及炎症因子的分泌在OLP中的作用受到越来越多的关注,已有研究证明2⁃脱氧⁃D⁃葡萄糖(2⁃deoxy⁃D⁃glucose,2⁃DG)或雷帕霉素(rapamycin,RAPA)抑制T细胞糖酵解代谢,进而抑制OLP的发生。本文就近年来关于糖酵解代谢相关转运蛋白、酶及调控因子在OLP中的研究进展进行综述。

Oral lichen planus(OLP)is a chronic inflammatory disease of the oral mucosa.The pathogenesis of OLP is still unclear.Immune abnormalities mediated by T cells and related cytokines play a crucial role in the pathogenesis of OLP.In recent years,glycolytic metabolism-related transporters,enzymes and regulators,such as glucose transporter-1(Glut1),glyceraldehyde 3-phosphate dehydrogenase(GAPDH),lactate dehydrogenase A(LDHA),mammalian target of rapamycin(mTOR)and hypoxia inducible factor-1α(HIF-1a),have attracted an increasing amount of attention in OLP by regulating the proliferation and differentiation of T cells and the secretion of inflammatory factors.It has been shown that 2-deoxy-D-glucose(2-DG)or rapamycin(RAPA)inhibits the glycolytic metabolism of T cells and then inhibits OLP.This article reviews the research progress of glycolytic metabolism-related transporters,enzymes and regulatory factors in OLP in recent years.