生殖免疫检测在女性不孕不育中的临床应用分析

Clinical application analysis of reproductive immunity test in female infertility

目的分析生殖免疫检测在女性不孕不育中的应用效果。方法选取1400例女性不孕不育患者作为观察组,另选取1000例正常生育的女性作为对照组。所有研究对象均进行生殖免疫检测,主要包括生殖抗心磷脂抗体(AcAb)[免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]、抗精子抗体(AsAb)和抗子宫内膜抗体(EmAb)。比较两组生殖抗心磷脂抗体(IgA、IgM、IgG)、抗精子抗体、抗子宫内膜抗体阳性情况,并分析各项抗体检测原发性、复发性、继发性不孕不育阳性情况。结果观察组IgA、IgM、IgG、抗精子抗体、抗子宫内膜抗体阳性率分别为14.36%、22.93%、8.93%、15.79%、23.00%,对照组IgA、IgM、IgG、抗精子抗体、抗子宫内膜抗体阳性率均为0。观察组IgA、IgM、IgG、抗精子抗体、抗子宫内膜抗体阳性率高于对照组,差异有统计学意义(P<0.05)。生殖抗心磷脂抗体检测原发性不孕不育阳性110例(7.86%),复发性不孕不育阳性337例(24.07%),继发性不孕不育阳性87例(6.21%);抗精子抗体检测原发性不孕不育阳性102例(7.29%),复发性不孕不育阳性62例(4.43%),继发性不孕不育阳性57例(4.07%);抗子宫内膜抗体检测原发性不孕不育阳性98例(7.00%),复发性不孕不育阳性104例(7.43%),继发性不孕不育阳性120例(8.57%)。结论女性不孕不育采取生殖免疫检测效果较强,能够为临床医生提供科学依据,从而实施针对性治疗,因此值得推广采纳。

Objective To analyze the actual effect of reproductive immunity test in female infertility.Methods 1400 female infertility patients were selected as the observation group,and 1000 women with normal reproductive history were selected as the control group.All subjects were tested for reproductive immunity,which mainly included reproductive anti-cardiolipin antibodies(AcAb)[immunoglobulin A(IgA),immunoglobulin M(IgM),immunoglobulin G(IgG)],anti-sperm antibodies(AsAb)and anti-endometrial antibodies(EmAb).The positive status of reproductive anti-cardiolipin antibodies(IgA,IgM,IgG),anti-sperm antibody and antiendometrial antibody were compared between the two groups,and the positive status of primary,recurrent and secondary infertility was analyzed by various antibody tests.Results The positive rates of IgA,IgM,IgG,antisperm antibody and anti-endometrial antibody were 14.36%,22.93%,8.93%,15.79%and 23.00%in the observation group,and 0 in the control group.The positive rates of IgA,IgM,IgG,anti-sperm antibody and antiendometrial antibody in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The detection of reproductive anti-cardiolipin antibody showed 110 cases(7.86%)were positive for primary infertility,337 cases(24.07%)were positive for recurrent infertility and 87 cases(6.21%)were positive for secondary infertility;the detection of antisperm antibody showed 102 cases(7.29%)were positive for primary infertility,62 cases(4.43%)were positive for recurrent infertility,and 57 cases(4.07%)were positive for secondary infertility;the detection of anti-endometrial antibody showed that 98 cases(7.00%)were positive for primary infertility,104 cases(7.43%)were positive for recurrent infertility,and 120 cases(8.57%)were positive for secondary infertility.Conclusion The reproductive immunity test for female infertility is effective and can provide scientific basis for clinicians to implement targeted treatment,so it is worth popularizing and adopting.