脓毒症性肌病的治疗研究进展

Advances in therapeutic methods of sepsis-induced myopathy

脓毒症性肌病(sepsis-induced myopathy,SIM)是由脓毒症引起的多种病理生理学机制相互关联导致的肌病,主要累及四肢肌、呼吸肌和膈肌,引起肌力下降、肌肉萎缩,严重降低患者生活质量,增加脓毒症患者远期病死率。而SIM发病机制复杂,至今尚不明确。目前,临床治疗包括早期功能锻炼、营养结构调节、功能电刺激等,针对脓毒症发病机制中导致肌肉萎缩重要靶点的相关药物研究及干细胞移植等治疗尚需进一步探索。

Sepsis-induced myopathy(SIM)is caused by a variety of pathophysiological mechanisms related to sepsis.It mainly endangers the limbs,respiratory muscles and diaphragm,causing the decline of muscle strength and muscle atrophy,which seriously reduces the quality of life and increases the long-term mortality of patients with sepsis.However,the pathogenesis of SIM is very complicated and still unclear.The current treatment includs early functional exercise,dietary structure adjustment,functional electrical stimulation.The possible target drug therapeutic research and stem cell transplantation need to be further explored.