穴位针刺疗法联合昂丹司琼治疗乳腺癌术后化疗相关性恶心呕吐的临床效果

Clinical Effect of Acupoint Acupuncture Combined with Ondansetron in the Treatment of Postoperative Chemotherapy Associated Nausea and Vomiting of Breast Cancer

目的穴位针刺疗法联合昂丹司琼治疗乳腺癌术后化疗相关性恶心呕吐(CINV)的效果。方法选取河南省肿瘤医院2019年9月至2021年9月收治的乳腺癌术后患者98例,采用随机数字表法分为对照组(n=52)和针刺组(n=46)。对照组接受昂丹司琼,针刺组在此基础上接受穴位针刺疗法。对比两组临床疗效,在急性期、迟发期和持续期的恶心视觉模拟评分(VAS)和呕吐次数、生活功能量表(FLIE)评分和卡氏功能状态(KPS)评分及血清5-羟色胺(5-HT)水平变化。结果经过治疗后,在急性期、迟发期和持续期针刺组治疗有效率较高(P<0.05);治疗后针刺组在急性期、迟发期和持续期恶心VAS评分和呕吐次数较对照组低(P<0.05);针刺组在急性期、迟发期和持续期FLIE评分和KPS评分较对照组高(P<0.05);针刺组在急性期、迟发期和持续期血清5-HT水平较对照组低(P<0.05)。结论采用穴位针刺疗法联合昂丹司琼治疗乳腺癌术后CINV具有较好的疗效,能够减少恶心呕吐次数,提高患者生活质量,值得在临床上推广应用。

Objective To observe the efficacy of acupoint acupuncture combined with ondansetron in the treatment of postoperative chemotherapy-associated nausea and vomiting(CINV)of breast cancer.Methods The 98 postoperative breast cancer patients admitted to Henan Cancer Hospital from September 2019 to September 2021 were selected and divided into control group(n=52)and acupuncture group(n=46)by random number table method.The control group received ondansetron,and the acupuncture group received acupoint acupuncture on this basis.The clinical efficacy,visual analogue scale(VAS)score and times of vomiting,functional living index-emesis(FLIE)score and Karnofsky performance status(KPS)score and changes in serum 5-hydroxy tryptamine(5-HT)level were compared between the two groups.Results After treatment,the effective rate of acupuncture in acute stage,late stage and duration stage was higher(P<0.05).Compared with the control group,the VAS score and vomiting times in acute,late and persistent stages were lower in acupuncture group after treatment(P<0.05).FLIE score and KPS score in acupuncture group were higher than those in control group in acute stage,late stage and duration period(P<0.05).The serum 5-HT level in acupuncture group was lower than that in control group in acute stage,late stage and duration stage(P<0.05).Conclusion Acupoint acupuncture combined with ondansetron in the treatment of postoperative CINV for breast cancer has good efficacy,can reduce the number of nausea and vomiting,improve the quality of life of patients,and is worthy of clinical application.