腰大池持续引流在神经内镜微创手术治疗高血压脑出血中的应用效果

Application effects of lumbar cistern continuous drainage in neuroendoscopic minimally invasive surgery for hypertensive cerebral hemorrhage

目的:探讨腰大池持续引流(LCFD)在神经内镜微创手术治疗高血压脑出血(HICH)中的应用效果。方法:选取2020年1月至2021年6月该院收治的60例HICH患者进行前瞻性研究,采用随机数字表法将其分为对照组和观察组各30例。对照组行神经内镜微创手术治疗,观察组在对照组基础上辅以LCFD治疗。比较两组术区引流时间、住院时间、手术前后神经功能指标[神经元特异性烯醇化酶(NSE)、脑源性神经营养因子(BDNF)水平和美国国立卫生研究院卒中量表(NIHSS)评分],以及并发症发生率、预后情况。结果:观察组术区引流时间、住院时间均短于对照组,差异有统计学意义(P<0.05);观察组术后NSE水平、NIHSS评分低于对照组,BDNF水平高于对照组,预后情况优于对照组,差异均有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:LCFD联合神经内镜微创手术治疗HICH患者能够缩短术区引流时间和住院时间,改善患者神经功能,使患者获得更好的预后,效果优于单用手术治疗。

Objective:To investigate application effects of lumbar cistern continuous drainage(LCFD)in neuroendoscopic minimally invasive surgery for hypertensive cerebral hemorrhage(HICH).Methods:A prospective study was conducted on 60 HICH patients admitted to this hospital from January 2020 to June 2021.They were divided into control group and observation group by using the random number table method,30 cases in each group.The control group was treated with neuroendoscopic minimally invasive surgery,while the observation group was treated with LCFD on the basis of that of the control group.The drainage time,the hospitalization time,the Indicators of neurological function before and after surgery[neuron-specific enolase(NSE),brain-derived Neurotrophic factor(BDNF)levels and National Institutes of Health Stroke Scale(NIHSS)score],the incidence of complications,and the prognosis were compared between the two groups.Results:The drainage time and he hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The NSE level and NIHSS score of the observation group were lower than that of the control group,and the BDNF level was higher than that of the control group,and the prognosis was better than that of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:LCFD combined with neuroendoscopic minimally invasive surgery for the HICH patients can shorten the drainage time and the hospitalization time,improve the neurological function,and improve the prognosis.Moreover,it is superior to single surgery.