盐酸氨溴索联合头孢噻肟治疗喘息性支气管炎患儿的效果

Effects of Ambroxol hydrochloride combined with Cefotaxime in treatment of children with asthmatic bronchitis

目的:观察盐酸氨溴索联合头孢噻肟治疗喘息性支气管炎患儿的效果。方法:选取2020年5月至2022年5月该院收治的60例喘息性支气管炎患儿进行前瞻性研究,根据随机数字表法将其分为对照组和观察组各30例。对照组采用头孢噻肟治疗,观察组在对照组基础上联合盐酸氨溴索治疗,比较两组临床疗效、症状消失时间(发热、喘息、咳嗽、哮鸣音)、住院时间、治疗前后血清炎性因子[降钙素原(PCT)、白细胞介素-6(IL-6)和C反应蛋白(CRP)]水平和治疗期间不良反应发生率。结果:观察组治疗总有效率为93.33%(28/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);观察组发热、喘息、咳嗽、哮鸣音等症状消失时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组血清PCT、IL-6、CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:盐酸氨溴索联合头孢噻肟治疗喘息性支气管炎患儿可缩短症状消失时间和住院时间,降低血清炎性因子水平,提高治疗总有效率,效果优于单纯头孢噻肟治疗。

Objective:To observe effects of Ambroxol hydrochloride combined with Cefotaxime in treatment of children with asthmatic bronchitis.Methods:A prospective study was conducted on 60 children with asthmatic bronchitis admitted to this hospital from May 2020 to May 2022.According to the random number table method,they were divided into control group and observation group,30 cases in each group.The control group was treated with Cefotaxime,while the observation group was treated with Ambroxol hydrochloride on the basis of that of the control group.The clinical efficacy,the symptom disappearance time(fever,wheezing,cough,wheezing),the hospitalization time,the levels of inflammatory factors[procalcitonin(PCT),interleukin-6(IL-6)and C-reactive protein(CRP)]before and after the treatment,and incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.33%(28/30),which was higher than 73.33%(22/30)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,wheezing,cough,wheezing and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PCT,IL-6 and CRP in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ambroxol hydrochloride combined with Cefotaxime in the treatment of the children with asthmatic bronchitis can shorten the symptom disappearance time and the hospitalization time,reduce the levels of inflammatory factors,and improve the total effective rate of treatment.Moreover,it is superior to single Cefotaxime treatment.