血清PAF、IL-10水平与子痫前期患者发生自发性早产的相关性

Correlations among serum PAF,IL-10 levels and spontaneous preterm birth in patients with preeclampsia

目的:分析血清血小板活化因子(PAF)、白细胞介素-10(IL-10)水平与子痫前期(PE)患者发生自发性早产(SPTB)的相关性。方法:选取2018年1月至2021年6月该院收治的105例PE患者进行前瞻性研究,根据随访结果分为早产组与非早产组,另选取该院同期100名非PE且正常分娩产妇,设为对照组,检测三组血清PAF、IL-10水平,并采用Pearson相关性分析血清PAF、IL-10水平与PE患者发生SPTB的相关性。结果:105例PE患者中,45例发生SPTB,占42.86%;非早产组、早产组血清PAF水平均高于对照组,且早产组高于非早产组,差异有统计学意义(P<0.05);非早产组、早产组的血清IL-10水平均低于对照组,且早产组低于非早产组,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,血清PAF水平与PE患者发生SPTB呈正相关(r>0,P<0.05),血清IL-10水平与PE患者发生SPTB呈负相关(r<0,P<0.05)。结论:血清PAF水平与PE患者发生SPTB呈正相关,血清IL-10水平与PE患者发生SPTB呈负相关。

Objective:To analyze correlations among serum platelet activating factor(PAF),interleukin-10(IL-10)levels and spontaneous preterm birth(SPTB)in patients with preeclampsia(PE).Methods:A prospective study was conducted on 105 PE patients admitted to the hospital from January 2018 to June 2021.According to whether SPTB occurred,they were divided into preterm group and non-preterm group.In addition,100 non-PE and normal delivery women in the same period were selected as control group.The levels of serum PAF and IL-10 in the three groups were detected.Pearson correlation analysis was used to analyze the correlations among the serum PAF and IL-10 levels and SPTB in the PE patients.Results:SPTB occurred in 45 of the 105 patients with PE,accounting for 42.86%.The level of pyretic serum PAF in the non-preterm and preterm groups was higher than that in the control group,and the preterm group was higher than that in the non-preterm group,with statistical significance(P<0.05).The levels of serum IL-10 in the non-preterm and preterm groups were lower than those in the control group,and the preterm group was lower than the non-preterm group,the difference was statistically significant(P<0.05);Pearson correlation analysis showed that the serum PAF level was positively correlated with SPTB in the PE patients(r>0,P<0.05),and the serum IL-10 level was negatively correlated with SPTB in the PE patients(r<0,P<0.05).Conclusions:The serum PAF level is positively correlated with SPTB in the PE patients,and the serum IL-10 level is negatively correlated with SPTB.