维甲酸在脑缺血及卒中后抑郁中的作用

The role of retinoic acid in cerebral ischemia and post-stroke depression

脑缺血及缺血后再灌注过程的病理生理机制复杂,发病后可能伴随卒中后抑郁等精神障碍,对人类生命和生活质量产生很大的威胁。目前的溶栓和取栓治疗具有极大限制性,寻求一种理想的神经保护药物对于治疗脑缺血有极其重要的临床意义。近年研究发现维甲酸不仅可通过调节炎症反应、保护血脑屏障、抗凋亡、促进神经再生等过程对脑缺血性疾病发挥保护作用,并且血清维甲酸水平在脑缺血及卒中后抑郁中可作为一项独立的指标发挥预测作用。该文将针对维甲酸在脑缺血及卒中后抑郁中的作用进行综述。

The pathophysiological mechanism of cerebral ischemia and post-ischemic reperfusion process is complex,and it may be accompanied by mental disorders such as post-stroke depression after the onset,which poses a great threat to human life.Current thrombolysis and thrombectomy treatments are extremely restrictive,and the search for an ideal neuroprotective drug is of great clinical significance for the treatment of cerebral ischemia.Recent studies have found that retinoic acid can not only play a protective role against cerebral ischemic diseases by regulating inflammatory response,protecting the blood-brain barrier,anti-apoptosis,and promoting nerve regeneration,but also serum retinoic acid levels can play an independent predictive role in cerebral ischemia and post-stroke depression.This article will review the role of retinoic acid in cerebral ischemia and post-stroke depression.