运动、自噬和瘦素抵抗

Exercise,autophagy and leptin resistance

瘦素抵抗是人类肥胖症的主要危险因素,高瘦素水平未能抑制摄食和减轻体重,导致机体能量调节失衡。自噬是一种细胞质量控制机制,可对细胞内物质进行周转。许多人类重大疾病的发生与自噬过程有关,如肥胖症、糖尿病和神经退行性疾病等。当细胞自噬出现障碍即自噬缺陷时,会导致机体发生瘦素抵抗。研究发现,运动是维持细胞稳态的自噬有效诱导剂,机体瘦素敏感性的提高可能与运动促进细胞自噬有关,但目前尚缺乏直接证据。

Leptin resistance is a major risk factor for human obesity,because high concentration of leptin fails to inhibit food intake and body weight,resulting in an imbalance between energy intake and energy expenditure.Autophagy is a cellular quality control mechanism that can recycle intracellular substances.Autophagy is strongly related to the occurrence of many major human diseases,including obesity,diabetes,neurodegenerative diseases,etc.It has been reported that autophagy defect can lead to leptin resistance.In addition,exercise is an effective inducer of autophagy that contributes to maintain cell homeostasis.But there is no direct evidence that exerciseinduced autophagy may be related to the increase in leptin sensitivity.