运动与二甲双胍调节肝脏脂代谢的作用机制研究进展

Research progress on the mechanism of exercise and metformin in regulating liver lipid metabolism

肝脏脂代谢紊乱与2型糖尿病、肥胖症、心血管疾病等多种慢性病密切相关。运动与二甲双胍均可通过作用于不同组织器官调节机体脂代谢,是防治脂代谢异常相关疾病的有效手段。运动可减少肝脏脂质摄入与分泌、降低脂质合成、促进脂肪酸分解,二甲双胍可抑制肝脏糖异生及脂质合成,达到控糖减脂的作用。两者在激活AMPK信号通路、促进肝脏因子分泌方面表现为协同效应,而对线粒体复合物I活性的调节却表现为拮抗效应,两者联合作用于肝脏脂代谢的分子机制有待进一步研究。该文基于运动与二甲双胍调控肝脏脂代谢的生物学机制进行综述,为慢病预防和治疗提供新的思路与策略。

Abnormal liver lipid metabolism is closely related to many chronic diseases,such as type 2 diabetes,obesity and cardiovascular diseases.Both exercise and metformin can regulate lipid metabolism by acting on different tissues and organs,which are effective methods for the treatment of chronic metabolic diseases that related to liver lipid metabolism disorder.Exercise has been reported to decrease lipid intake and output,reduce lipid synthesis and promote fatty acid oxidation in liver,and metformin is effective at controlling glycolipid metabolism by inhibiting hepatic gluconeogenesis and lipid synthesis.They have synergistic effects in activating AMPK signaling pathway and promoting hepatokines secretion,while they show antagonistic effects in regulating mitochondrial complex I activity.Thus,the molecular mechanism of their combined effects on hepatic lipid metabolism needs to be further studied.The present article reviews the main mechanisms of exercise and metformin in regulating liver lipid metabolism,providing new ideas and strategies for the prevention and treatment of chronic metabolic diseases.