摘要
Dear Editor,Male subfertility,a multifactorial disease affecting~7%of the global male population,is usually caused by abnormalities in sperm flagella.The flagella and motile cilia have similar“9+2”axonemes and are evolutionarily conserved,being widely distributed in bacteria,archaea and eukaryotes1.Cilia defects also lead to primary ciliary dyskinesia(PCD),which affects approximately 1/10,000 individuals worldwide.
基金
This work was supported by the National Key Research and Development Program of China(2022YFC2702702 to M.L.and 2022YFC2702604 to Y.T.)
the National Natural Science Foundation of China(32270899 and 32070842 to M.L.,82101961,82171608,82201773 and 81971447 to Y.T.)
the Natural Science Foundation of Jiangsu Province(BK20190081 to M.L.)
Changsha Municipal Natural Science Foundation(kq2202493 to S.Y.).We sincerely appreciate Zhuang Xiao and Shuqin Zhao from State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Chen Tan,Huan Zhang,Chaofeng Tu,Qinwei Zhou,Fei Meng,Qianjun Zhang,and Chunbo Xie from Reproductive and Genetic Hospital of CITIC-XIANGYA for their assistance in this study.
