摘要
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the global pandemic coronavirus disease 2019(COVID-19),has proven itself to be a highly virulent respiratory pathogen with an unpredictable evolutionary capacity,posing a persistent threat to mankind.At the time of this manuscript’s publication.
基金
This work was supported by Shenzhen Science and Technology Program(JSGG20200225150431472,JSGG20210901145403012&KQTD20180411143323605)
Guangdong Basic and Applied Basic Research Foundation(Grant#2020A1515110361)
National Key Research and Development Program of China(#2021YFC0865100)
Key-Area Research and Development Program of Guangdong Province(2021B1111110001)
National Natural Science Foundation of China(grant#32041002,#82150206)
D.G.is also supported by Guangdong Zhujiang Talents Program(#2016LJ06Y540)and National Ten-thousand Talents Program.The authors thank Lu Zhang,Ruyan Liao,Yongxia Shi and Jun Dai from Guangzhou Customs District Technology Center for the help in in vivo efficacy experiment.We also thank the other project participants,including Guanguan Li,Shuo Li and Xinjun Liu from Medi-X Pingshan,Southern University of Science and Technology for the support in preclinical study.
