摘要
Dear Editor,To date,seven human coronaviruses(HCoVs)have been identified,among which the highly pathogenic severe acute respiratory syndrome-associated coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have caused public health disasters worldwide.
基金
This study was funded by grants from the National Key Research and Development Program(2021YFC2300603)
the National Science Foundation of China(32170157,Key program 81830017,and 81902051),Taishan Scholarship(No.tspd20181201)
Major Basic Research Project of Shandong Natural Science Foundation(No.ZR2020ZD12)
Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong,Key Research and Development Program of Shandong(2019GSF108238).We thank Professor Jincun Zhao(the First Affiliated Hospital of Guangzhou Medical University)for the friendly gifted HCoV-229E virus and S protein expression plasmids of HCoV-NL63 and HCoV-229E.We thank the Translational Medicine Core Facility of Shandong University for the consultation and instrument availability that supported this work.
