恶性肿瘤中上皮-间质转化与多种信号通路关系的研究进展

Research progress on the relationship between epithelial-mesenchymal transition and multiple signaling pathways in malignant tumors

近年来,恶性肿瘤的发病率逐年上升,严重危害人类的健康。上皮-间质转化(EMT)在恶性肿瘤侵袭和转移中发挥了关键作用,Wnt、NF-κB、PI3K、TGF等信号通路以及表皮生长因子(EGF)和微小核糖核酸(miRNA)等均参与了EMT的形成过程。本文结合以上信号通路及相关因子对EMT在各系统恶性肿瘤发病和侵袭转移中的作用做简要综述。

In recent years,the incidence of malignant tumors is increasing year by year,which seriously endangers human health.Epithelial-mesenchymal transformation(EMT)plays a key role in the invasion and metastasis of malignant tumors.Wnt,NF-κB,PI3K,TGF and other signaling pathways,epidermal growth factor(EGF)and microribonucleic acid(miRNA)are involved in the formation of EMT.This article will briefly review the role of EMT in the pathogenesis,invasion and metastasis of malignant tumors in various systems by combining the above signaling pathways and related factors.